SIELC Technologies
SIELC Technologies is the manufacturer of i.e. Primesep®, Promix™ and Obelisc™ columns.
Products:
Newcrom, A column with a new outer design.This column and corresponding adapter entirely eliminate the need for any high-pressure fittings or tubing as well as minimizing all possible dead volumes. Furthermore, if a leak ever occurs in the high-pressure column inlet, the mobile phase is contained within the column adapter (no external leakage). Read more.
PEI (Polyethylenimine) specific column was designed to combine ion-exclusion and size-exclusion phenomena to allow for separation of PEI polymers from most other higher- and lower-molecular-weight compounds and excess of Cu (II) ions.
Primesep® stationary phases offer unprecedented selectivity in the separation of a broad array of chemical compounds and in multiple applications. A wide range of HPLC columns with id's from 0.5 mm to 22 mm is available. Corresponding Primesep guard columns are available with all stationary phases and do not require holders. SIELC offers a method development service is available for customers. Ask about special custom LC-phases tailored for specific separations.
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Column Hardware
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FlipLC
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Obelisc™, Two complimentary columns, Obelisc R and Obelisc N, based on Liquid Separation Cell ( LiSC ™) technology, offer a new approach to separate a variety of small molecules. Buffer concentration, buffer pH, and organic modifier concentration are three orthogonal parameters of the mobile phase that allow adjustment of column properties to separate complex mixtures.
SHARC™,is the latest, innovative column from SIELC Technologies. SHARC™ columns are the first commercially available columns with separation based primarily on hydrogen bonding. SHARC stands for Specific Hydrogen-bond Adsorption Resolution Column.
Hydrogen bonding is an interaction (attraction) of bound hydrogen atom to the molecules with electronegative atoms such as oxygen, nitrogen, fluorine.
Promix™, is an alternative chromatography technology for efficient resolution of peptides and proteins. The technology is based on a combination of two interactions - hydrophobic and ionic. This approach is possible due to a new type of separation media: a chemical combination of hydrophobic and ionic functional groups on a ligand bonded to a silica support. With this phase, unparalleled selectivity and peak capacity can be achieved. Independent adjustment of the amount of buffer and organic modifier creates an infinite number of separation conditions that are suitable for many types of biomolecules.
Hydrogen bonding is an interaction (attraction) of bound hydrogen atom to the molecules with electronegative atoms such as oxygen, nitrogen, fluorine.
Promix™, is an alternative chromatography technology for efficient resolution of peptides and proteins. The technology is based on a combination of two interactions - hydrophobic and ionic. This approach is possible due to a new type of separation media: a chemical combination of hydrophobic and ionic functional groups on a ligand bonded to a silica support. With this phase, unparalleled selectivity and peak capacity can be achieved. Independent adjustment of the amount of buffer and organic modifier creates an infinite number of separation conditions that are suitable for many types of biomolecules.
Legacy™, SIELC has developed the Legacy column, which can be used in many USP Validated methods. SIELC is developing L1, L3, L7, L8, L10, L11, L14, L16, L26, L28, and L44 columns.
FlipLC ™ Samples from natural sources, such as fruits, vegetables, culinary products, water, soil, and bodily fluids, are complex mixtures consisting of multiple compounds. FlipLC method removes impurities from the complex samples, shortens chromatography run time, and increases the lifetime of the columns. It requires minimum sample preparation. The isolation column flips direction and position in the flow path during this process, that is why we call it FlipLC.
Devices Different devices often used in chromatography applications to build special capabilities of the instrumentation. SIELC Technologies is offering several innovative devices:
- High pressure switching valve
- HPLC binary pump
- UV-Vis detector