YMC Europe
YMC-Pack ODS-A
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fully endcapped C18 material classic "workhorse” phase highly versatile ODS phase for polar to moderately nonpolar pharmaceuticals, organic chemicals, biologicals and natural products
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YMC-Pack ODS-A
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Specification
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Specification
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Specification
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Particle size / µm
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3; 5
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3; 5
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5; 10
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Pore size / nm
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12
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20
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30
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Surface area / m2g-1
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330
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175
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100
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Carbon content / %
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17
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12
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7
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Recommended pH range
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2.0 - 7.5
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2.0 - 7.5
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2.0 - 7.5
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General
YMC-Pack ODS-A, YMC’s classic reversed phase column, is renowned worldwide because of its unique performance and reproducibility. Due to this high quality, YMC-Pack ODS-A is successfully used for the validation of analytical HPLC methods and for long term reproducible preparative HPLC processes.
Properties
The production of the base silica for ODS-A and the subsequent derivatisation process are both performed in large bulk batches to give large quantities of highly reproducible material. Exhaustive endcapping reliably reduces the activity of residual silanol groups and minimises non-specific secondary retention.
In addition to standard characterisation methods such as the determination of adsorption isotherms, particle size distribution and carbon content, YMC applies an extensive range of analytical methods to ensure constant and reproducible selectivity of the reversed phase packings.
The base of YMC-Pack ODS-A is YMC’s ultrapure silica. This is of great consequence because metal contaminants in silica can cause significant tailing of sample molecules such as acetylacetone or 8- hydroxyquinoline by formation of coordination complexes on the silica surface.
As coordinating functional groups are frequent structural components in pharmaceutical compounds, ultrapure packings such as YMC-Pack ODS-A are needed for reproducible separation of these compounds without secondary retention or tailing.
YMC-Pack ODS-A is frequently used for pharmaceutical, biochemical and environmental applications as well as for separations in the field of food technology.
YMC-Pack ODS-A phases are available in the particle size range from 3 to 50 μm. As the selectivity is identical throughout the whole range, these phases are ideal for scale-up from analytical to preparative process scale.
In addition to standard characterisation methods such as the determination of adsorption isotherms, particle size distribution and carbon content, YMC applies an extensive range of analytical methods to ensure constant and reproducible selectivity of the reversed phase packings.
The base of YMC-Pack ODS-A is YMC’s ultrapure silica. This is of great consequence because metal contaminants in silica can cause significant tailing of sample molecules such as acetylacetone or 8- hydroxyquinoline by formation of coordination complexes on the silica surface.
As coordinating functional groups are frequent structural components in pharmaceutical compounds, ultrapure packings such as YMC-Pack ODS-A are needed for reproducible separation of these compounds without secondary retention or tailing.
YMC-Pack ODS-A is frequently used for pharmaceutical, biochemical and environmental applications as well as for separations in the field of food technology.
YMC-Pack ODS-A phases are available in the particle size range from 3 to 50 μm. As the selectivity is identical throughout the whole range, these phases are ideal for scale-up from analytical to preparative process scale.
Column care
YMC-Pack ODS-A is stable towards hydrolysis between pH 2-7,5. Remove acid and buffer salts before storage. Store the column in methanol / water = 70/30. Clogged inlet frits often can be cleaned by changing the flow direction or replacement.
For detailed information please refer to the "Column Care and Use Instructions”, which are shipped with each analytical column.
YMC-Pack ODS-A is stable towards hydrolysis between pH 2-7,5. Remove acid and buffer salts before storage. Store the column in methanol / water = 70/30. Clogged inlet frits often can be cleaned by changing the flow direction or replacement.
For detailed information please refer to the "Column Care and Use Instructions”, which are shipped with each analytical column.
YMC Reversed-Phase brochure, including ordering information