| Fuctional Group |
Silylation |
Acylation |
Alkylation |
|
|
|
|
| Active Hydrogens |
BSA, BSTFA, BSTFA/TCMS, Deriva-Sil, Hydrox-Sil, MSTFA, MTBSTFA, TMSI |
PFPOH/PFPA |
DMF Dialkylacetals, TBH |
| Carboxylic Acids |
BSTFA, Hydrox-Sil Conc., MSTFA, TMSI |
PFPOH/PFPA |
BF3/Methanol, BF3/n-Butanol, DMF Dialkylacetals |
| Alcohols and Phenols: unhindered and moderately hindered |
BSA, BSTFA/TCMS, HMDS, MTBSTFA/t-BDMCS |
HFBI, Fluorinated Anhydrides (HFBA, PFPA, TFAA), MBTFA, MCF* |
DMF Dialkylacetals, PFB-Br/TBA-H-SO4, TBH |
| Alcohols and Phenols: highly hindered |
BSTFA/TCMS, Deriva-Sil, Deriva-Sil Conc. |
Fluorinated Anhydrides, (HFBA, PFPA, TFAA), HFBI, PFBCI |
DMF Dialkylacetals, PFB-Br/TBA-H-SO4, TBH |
| Amines: primary and secondary |
BSTFA, MTBSTFA/t-BDMCS |
Fluorinated Anhydrides, (HFBA, PFPA, TFAA), HFBI, MBTFA, PFBCI, TPC* |
DMF Dialkylacetals, TBH |
| Amides |
BSA, BSTFA, BSTFA/TMCS, Deriva-Sil Conc. |
HFBI |
DMF Dialkylacetals, TBH |
| Amino Acids |
BSTFA, TMS |
IHFBI (+ Silyation) |
DMF Dialkylacetals, TBH |
| Catechloamines |
TMSIFluorinated Anhydrides, (HFBA, PFPA, TFAA), HFBI |
TMSIFluorinated Anhydrides, (HFBA, PFPA, TFAA), HFBI |
|
| Carbohydrates and Sugars |
HMDS, Hydrox-Sil AQ, TMSI |
MBTFA |
|
| Inorganic Anions |
BSTFA, MTBSTFA |
|
|
| Nitrosamines |
|
HFBA |
|
| Sulfonamides |
BSTFA |
Fluorinated Anhydrides, (HFBA, PFPA, TFAA) |
DMF Dialkylacetals, PFB-Br/TBA-H-SO4 |
| Derivatization reagents are listed in alphabetical order, not in order of preference |
