Macherey-Nagel GmbH
NUCLEODUR® high purity silica phases for HPLC
NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:
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totally spherical particle shape
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outstanding surface microstructure
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high pressure stability
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low metal content
Download the Nucleodur Catalog, or an overview of available NUCLEODUR® phases.
NUCLEODUR® as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.
NUCLEODUR® is also available with 1.8 µm particle size for increased separation efficiency
| Summary of available NUCLEODUR® phases | |||||
| Phase | Modification | % C | pH range | Particle sizes [µm] | USP |
| C18 Gravity | octadecyl, high density coating, multi-endcapping | 18 | 1–11 | 1.8 · 3 · 5 | L1 |
| C18 Gravity-SB | octadecyl (monomeric), extensive endcapping | 13 | 1–9 | 1.8 · 3 · 5 | L1 |
| C8 Gravity | octyl, high density coating, multi-endcapping | 11 | 1–11 | 1.8 · 5 | L7 |
| C18 Isis | octadecyl, specially cross-linked modification, endcapped | 20 | 1–10 | 1.8 · 3 · 5 | L1 |
| C18 Pyramid | octadecyl with polar endcapping | 14 | 1–9 | 1.8 · 3 · 5 | L1 |
| PolarTec | octadecyl with embedded polar group | 17 | 1–9 | 1.8 · 3 · 5 | L1 L60 |
| Phenyl-Hexyl | special phenylhexyl phase | 10 | 1–10 | 1.8 · 3 · 5 | L11 |
| PFP | pentafluorophenyl-propyl with multi-endcapping | 8 | 1–9 | 1.8 · 3 · 5 | L43 |
| Sphinx RP | bifunctional, balanced ratio of propylphenyl and octadecyl, endcapping | 15 | 1–10 | 1.8 · 3 · 5 | L1 L11 |
| C18 HTec | octadecyl, high density coating, high capacity, multi-endcapping | 18 | 1–11 | 1.8 · 3 · 5 | L1 |
| C18 ec | octadecyl, medium density, endcapping | 17.5 | 1–9 | 3 · 5 | L1 |
| C8 ec | octyl, medium density, endcapping | 10.5 | 1–9 | 3 · 5 | L7 |
| C4 ec | butyl, medium density, endcapping | 2.5 | 1–9 | 5 | L26 |
| HILIC | ammonium – sulfonic acid | 7 | 2–8.5 | 1.8 · 3 · 5 | |
| CN/CN-RP | cyano (nitrile) for NP and RP separations | 7 | 1–8 | 3 · 5 | L10 |
| NH2/NH2-RP | aminopropyl for NP and RP separations | 2.5 | 2–8 | 3 · 5 | L8 |
| SiOH | unmodified NUCLEODUR® | – | 2–8 | 3 · 5 | L3 |