Regis Technologies
Chiral Chromatography
α-Burke 2
Analytical to Preparative Columns
The α-Burke 2 phase is derived from dimethyl N-3,5-dinitro-benzoyl--amino-2,2-dimethyl- 4-pentenyl phosphonate covalently bound to 5 µm silica. This π-acceptor chiral stationary phase is particularly valuable in the HPLC separation of β-blocker enantiomers, an important class of cardiovascular drugs whose enantiomers often exhibit differing pharmacological activities. The α-Burke 2 has been specifically designed to separate the enantiomers of β-blockers without chemical derivatization. In addition, it also resolves the enantiomers of many compounds separated on π-acceptor Pirkle type chiral stationary phases.
The α-Burke 2 phase is derived from dimethyl N-3,5-dinitro-benzoyl--amino-2,2-dimethyl- 4-pentenyl phosphonate covalently bound to 5 µm silica. This π-acceptor chiral stationary phase is particularly valuable in the HPLC separation of β-blocker enantiomers, an important class of cardiovascular drugs whose enantiomers often exhibit differing pharmacological activities. The α-Burke 2 has been specifically designed to separate the enantiomers of β-blockers without chemical derivatization. In addition, it also resolves the enantiomers of many compounds separated on π-acceptor Pirkle type chiral stationary phases.
| Product | Particle size | Dimension | Code |
| Spherical Silica | |||
| (R)-Þ-Burke 2 | 5 µm, 100 Å | 25 cm x 10.0 mm i.d. | 735235 |
| (R)-Þ-Burke 2 | 5 µm, 100 Å | 25 cm x 21.1 mm i.d. | 735236 |
| (R)-Þ-Burke 2 | 5 µm, 100 Å | 25 cm x 4.6 mm i.d. | 735035 |
| (S)-Þ-Burke 2 | 5 µm, 100 Å | 25 cm x 10.0 mm i.d. | 735237 |
| (S)-Þ-Burke 2 | 5 µm, 100 Å | 25 cm x 21.1 mm i.d. | 735238 |
| (S)-Þ-Burke 2 | 5 µm, 100 Å | 25 cm x 4.6 mm i.d. | 735037 |